With the crew exonerated, Dom (Vin Diesel) and Letty (Michelle Rodriguez) are enjoying their honeymoon, while Brian (Paul Walker) and Mia (Jordana Brewster) have decided to retire from the game. It seems the globetrotting "family," including Roman (Tyrese Gibson), Tej (Ludacris), and Luke (Dwayne Johnson), are able to settle down and lead a more normal life.

However, when Dom suddenly betrays them to team up with a dangerous criminal terrorist named Cipher (Charlize Theron), the team is thrown into disarray. When Letty pleads with them not to give up on Dom, they joins forces with a top secret government ops team led by Mr. Nobody (Kurt Russell) and team up with Deckard Shaw (Jason Statham) in order to help stop Dom and his new anarchist boss from committing unspeakable acts of terror.