Anti-narcotics special operative Nina Manigan (Anne Curtis) is being integrated with a new Philippine Drug Enforcement Agency after surviving the slaughter of her entire squad in a drug raid compromised by dirty cops. She's teamed with fellow agent Rico Yatco (Brandon Vera).

Manigan, Yatco and the rest of their unit are assigned to taken down drug lord Biggie Chen. They have the help of drug dealer/stool pigeon Teban. The team descends into the seedy underbelly of a shantytown named Gracia ni Maria in Manila. Undercover agents are supposed to lure a drug dealer into a bogus deal so the agents can step in and arrest them. However, the sting operation quickly goes wrong and Manigan and her team find themselves trapped, hunted not only by the drug gangs, but the angry civilians who blame the police for their oppressed existence.