American doctor Ben McKenna (James Stewart), his wife Jo (Doris Day) and their son Hank are on a holiday in Africa when a man they met the day before is stabbed and collapses at their feet. With his last words he tells Ben of an assassination plot to take place in London. Fearing their plan will be revealed, the terrorists kidnap Hank to keep the McKennas silent and carry him off to England --with Ben and Jo in pursuit.

Alfred Hitchcock directed this color remake of his own 1934 original.